Synthesis,copolymerization and peptide-modification of carboxylic acid-functionalized 3,4-ethylenedioxythiophene (EDOTacid) for neural electrode interfaces |
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| Authors: | Laura K Povlich Jae Cheol Cho Michelle K Leach Joseph M Corey Jinsang Kim David C Martin |
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| Institution: | 1. Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA;3. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA;4. Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA;5. Geriatrics Research, Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare Center, Ann Arbor, MI 48105, USA;6. Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA;g Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA;h Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA |
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| Abstract: | BackgroundConjugated polymers have been developed as effective materials for interfacing prosthetic device electrodes with neural tissue. Recent focus has been on the development of conjugated polymers that contain biological components in order to improve the tissue response upon implantation of these electrodes.MethodsCarboxylic acid-functionalized 3,4-ethylenedioxythiophene (EDOTacid) monomer was synthesized in order to covalently bind peptides to the surface of conjugated polymer films. EDOTacid was copolymerized with EDOT monomer to form stable, electrically conductive copolymer films referred to as PEDOT-PEDOTacid. The peptide GGGGRGDS was bound to PEDOT-PEDOTacid to create peptide functionalized PEDOT films.ResultsThe PEDOT-PEDOTacid-peptide films increased the adhesion of primary rat motor neurons between 3 and 9 times higher than controls, thus demonstrating that the peptide maintained its biological activity.ConclusionsThe EDOT-acid monomer can be used to create functionalized PEDOT-PEDOTacid copolymer films that can have controlled bioactivity.General SignificancePEDOT-PEDOTacid-peptide films have the potential to control the behavior of neurons and vastly improve the performance of implanted electrodes. This article is part of a Special Issue entitled Organic Bioelectronics—Novel Applications in Biomedicine. |
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| Keywords: | Conjugated polymer Electrochemical Biomaterial RGD Neuron Adhesion |
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