Glutathione synthesis |
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| Authors: | Shelly C. Lu |
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| Affiliation: | Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine USC, Los Angeles, CA 90033, USA |
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| Abstract: | |
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| Keywords: | 4-HNE, 4-hydroxynonenal 15d-PGJ2, 15-deoxy-?12,14-prostaglandin J2 AP-1, activator protein-1 As3 +, trivalent arsenite α-SMA, a-smooth muscle actin ARE, antioxidant response element ATRA, all-trans retinoic acid BDL, bile duct ligation BHMT, betaine homocysteine methyltransferase β-NF, β-naphthoflavone BSO, buthionine sulfoximine CBS, cystathionine β synthase CMK, Ca2 +-calmodulin kinase II CNC-bZIP, cap &lsquo n&rsquo collar-basic leucine zipper proteins CREB, c-AMP-response element binding protein DEM, diethyl maleate ECM, extracellular matrix EpRE, electrophile response element GCL, glutamate-cysteine ligase GCLC, GCL-catalytic subunit GCLM, GCL-modifier subunit GGT, γ-glutamyltranspeptidase GPx, GSH peroxidase GS, GSH synthase GSH, glutathione GSSG, oxidized GSH HCC, hepatocellular carcinoma Hcy, homocysteine HGF, hepatocyte growth factor HSC, hepatic stellate cell iNOS, inducible nitric oxide synthase LPS, lipopolysaccharide MAT, methionine adenosyltransferase MRE, metal response element MS, methionine synthase MT, methyltransferase NFE2, nuclear factor erythroid 2 NO, nitric oxide Nrf2, nuclear factor-erythroid 2 related factor 2 PKA, protein kinase A PKC, protein kinase C RNS, reactive nitrogen species RXRα, retinoid X receptor α ROS, reactive oxygen species SAH, S-adenosylhomocysteine SAMe, S-adenosylmethionine TAA, thioacetamide TBH, tert-butyl hydroquinone TGF-β1, transforming growth factor-β1 TLR4, toll like receptor 4 TNFα, tumor necrosis factor α UDCA, ursodeoxycholic acid |
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