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Glutathione synthesis

Authors:	Shelly C Lu

Institution:	Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine USC, Los Angeles, CA 90033, USA

Abstract:

Keywords:	4-HNE 4-hydroxynonenal 15d-PGJ₂ 15-deoxy-?¹² 14-prostaglandin J₂ AP-1 activator protein-1 As³ + trivalent arsenite α-SMA a-smooth muscle actin ARE antioxidant response element ATRA all-trans retinoic acid BDL bile duct ligation BHMT betaine homocysteine methyltransferase β-NF β-naphthoflavone BSO buthionine sulfoximine CBS cystathionine β synthase CMK Ca² +-calmodulin kinase II CNC-bZIP cap &lsquo n&rsquo collar-basic leucine zipper proteins CREB c-AMP-response element binding protein DEM diethyl maleate ECM extracellular matrix EpRE electrophile response element GCL glutamate-cysteine ligase GCLC GCL-catalytic subunit GCLM GCL-modifier subunit GGT γ-glutamyltranspeptidase GPx GSH peroxidase GS GSH synthase GSH glutathione GSSG oxidized GSH HCC hepatocellular carcinoma Hcy homocysteine HGF hepatocyte growth factor HSC hepatic stellate cell iNOS inducible nitric oxide synthase LPS lipopolysaccharide MAT methionine adenosyltransferase MRE metal response element MS methionine synthase MT methyltransferase NFE2 nuclear factor erythroid 2 NO nitric oxide Nrf2 nuclear factor-erythroid 2 related factor 2 PKA protein kinase A PKC protein kinase C RNS reactive nitrogen species RXRα retinoid X receptor α ROS reactive oxygen species SAH S-adenosylhomocysteine SAMe S-adenosylmethionine TAA thioacetamide TBH tert-butyl hydroquinone TGF-β1 transforming growth factor-β1 TLR4 toll like receptor 4 TNFα tumor necrosis factor α UDCA ursodeoxycholic acid
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