| 衣原体免疫逃逸机制的研究进展 |
| |
| 引用本文： | 陈芝喜,陈丽丽,吴移谋. 衣原体免疫逃逸机制的研究进展[J]. 微生物学免疫学进展, 2012, 40(6): 64-67 |
| |
| 作者姓名： | 陈芝喜 陈丽丽 吴移谋 |
| |
| 作者单位： | 南华大学病原生物学研究所 |
| |
| 基金项目： | 国家自然科学基金(鹦鹉热嗜衣原体持续性感染的分子机制研究,31270218) |
| |
| 摘 要： | 衣原体是一类专性细胞内寄生的原核细胞型微生物,感染人体后可引起多种慢性疾病。衣原体在宿主细胞中复制和持续性存在是其致病的主要原因。近年的研究表明,衣原体通过改变MHC抗原表达、干扰宿主细胞凋亡信号通路等机制以逃逸宿主的免疫清除。
|
| 关 键 词： | 衣原体 MHC抗原 细胞凋亡 免疫逃逸 |
The immune escape mechanisms of Chlamydia |
| |
| CHEN Zhi-xi,CHEN Li-li,WU Yi-mou. The immune escape mechanisms of Chlamydia[J]. Progress In Microbiology and Immunology, 2012, 40(6): 64-67 |
| |
| Authors: | CHEN Zhi-xi CHEN Li-li WU Yi-mou |
| |
| Affiliation: | (Institute of Pathogen Biology,University of South China,Hunan Hengyang 421001,China) |
| |
| Abstract: | Chlamydia is a type of obligate intracellular prokaryotic microorganisms,which can cause many kinds of serious diseases in human.Duplication and persistent survival in host cells is its main pathogenic mechanism.In recent years,studies have shown that Chlamydia can escape host immune recognition and clearance by altering the MHC antigen expression and interfering the apoptosis signal pathway. |
| |
| Keywords: | Chlamydia MHC antigen Cell apoptosis Immune escape |
| 本文献已被 CNKI 等数据库收录！ |
