Host-microbe interactions: innate pattern recognition of fungal pathogens |
| |
Authors: | van de Veerdonk Frank L Kullberg Bart Jan van der Meer Jos W M Gow Neil A R Netea Mihai G |
| |
Institution: | Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands. |
| |
Abstract: | The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|