Wnt signaling as a potential therapeutic target for frontotemporal dementia |
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| Authors: | Korade Zeljka Mirnics Károly |
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| Affiliation: | Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA. zeljka.korade@vanderbilt.edu |
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| Abstract: | Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology. |
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