TAURINE IN DEVELOPING RAT BRAIN: MATERNAL-FETAL TRANSFER OF [35S]TAURINE AND ITS FATE IN THE NEONATE |
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| Authors: | J. A. Sturman D. K. Rassin G. E. Gaull |
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| Affiliation: | Department of Pediatric Research, Institute for Basic Research in Mental Retardation, Staten Island, NY 10314 and the Department of Pediatrics, Mount Sinai School of Medicine of the City University of New York, NY 10029, U. S. A. |
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| Abstract: | The transfer of [35] taunne, injected intrapentoneally into pregnant rats (near term), to fetal tissues has been measured. Taurine can enter fetal brain as easily as it can fetal liver. In contrast, it cannot enter mature brain as easily as it can enter mature liver. After birth, [35S] taurine, which had been injected into the dam before birth of the pups, continues to accumulate in the brain of the pups for some days. During the neonatal period, the concentration of taurine is decreasing, but the total pool of taurine in the brain is increasing rapidly. In order to help supply this increasing pool, the taurine present in the brain at birth appears to be conserved and an increasing amount of taurine is synthesized in situ. The net result during the neonatal period of development is that brain taurine specific radioactivity decreases and brain taurine has a very slow rate of turnover. |
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