Novel hemoglobin components and their amino acid sequences from the crab-eating macaque (Macaca fascicularis) |
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Authors: | Akiko Takenaka Kenji Takahashi Osamu Takenaka |
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Affiliation: | (1) Department of Biochemistry, Primate Research Institute, Kyoto University, 484 Inuyama, Aichi, Japan;(2) Present address: Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo, 113 Hongo, Tokyo, Japan |
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Abstract: | Summary We found two types of hemoglobin, T and R, from the crab-eating macaque and compared those to A and Q previously reported. The 22 animals studied showed six different phenotypes, A, R, QA, QT, QAT, and QAR. Analysis of the complete amino acid sequences for the chains of hemoglobins Q, A, T, and R revealed that amino acids at four positions, 8, 55, 71, and 78 from the N-terminal, are variable. In the A chain, Thr, Val, Gly, and Gln occupy these positions, and in the Q chain the analogous amino acids are Thr, Val, Asp, and Gln, respectively. In the newly found T chain they are Thr, Val, Gly, and His; and in the R chain, they are Ser, Ile, Gly, and His, respectively. Two amino acids (8 Thr and 79 Gln) in A of the crab-eating macaque were found to be different from those in the chain of the Japanese macaque. |
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Keywords: | /content/x47263126217r854/xxlarge945.gif" alt=" agr" align=" BASELINE" BORDER=" 0" > globin Crab-eating macaque Amino acid sequence |
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