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Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts |
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| Authors: | Xiaodong Zhou Wei Lin Filemon K Tan Shervin Assassi Mavin J Fritzler Xinjian Guo Roozbeh Sharif Tom Xia Syeling Lai Frank C Arnett |
| Affiliation: | (1) Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA;(2) Department of Medicine, University of Calgary, Calgary, AB, T2N 1N4, Canada;(3) Rice University, Houston, Post Office Box 1892, TX 77030, USA;(4) Departmant of Pathology, Baylor College of Medicine, Houston, TX 77030, USA |
| Abstract: | IntroductionSumoylation is involved in nucleolus-nucleoplasm transport of DNA topoisomerase I (topo I), which may associate with changes of cellular and topo I functions. Skin fibroblasts of patients with systemic sclerosis (SSc) exhibit profibrotic cellular changes. The aims of this study were to examine the catalytic function and sumoylation of topo I in the nuclei of SSc fibroblasts, a major cell type involved in the fibrotic process. |
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