The volumes of some compartment systems with sampling and loss from one compartment |
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Authors: | Peter B Bright |
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Institution: | (1) Department of Biophysics and Surgery, University of Texas Southwestern Medical School, 75235 Dallas, Texas |
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Abstract: | If the concentrationc
1(t)=∑
i=1
n
A
i
exp (−α
i
t) for one compartment, one presumes a linear catenaryn-compartment system without sinks and loss only from the same compartment, then the volumesV
i
, rate constantsk
ij
, and concentrationsc
i
(t) in each compartment can be determined in terms of theA
i
's,A
i
′s, α
i
′s, the dose injectedD
o
and the partition coefficientsr
ij
=k
ij
/k
ji
. If the concentration would become uniform at equilibrium, then the total volume of distribution may be determined without
knowledge ofr
ij
or restriction to catenary configuration. |
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Keywords: | |
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