Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer |
| |
| Authors: | Yi Dong Kee Sun In-Cheol Ryu Ju Hee Koo Heebeom Park Chul Wan Youn In-Chan Choi Kuiwon Kwon Ick Chan Kim Kwangmeyung Ahn Cheol-Hee |
| |
| Institution: | Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi-do 461-701, Korea. |
| |
| Abstract: | Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
