参与细胞自噬的蛋白质的翻译后修饰

细胞自噬是进化上高度保守的细胞分解代谢途径. 在代谢应激下激活，产生双层膜结构的自噬小体，将胞浆内受损细胞器和蛋白质包裹、转运至溶酶体降解，维持细胞内环境平衡，是一种典型的细胞质量控制机制.目前，经典自噬通路中的主要蛋白质已经明确.但代谢应激信号的输入引起这些蛋白质怎样的活性和功能变化，这些变化对自噬产生怎样的影响，却是知之甚少.本文从翻译后修饰角度对代谢应激状态下自噬过程中相关蛋白质的调节进行综述，有助于深入了解自噬过程.

Posttranslational Modifications of Autophagy-related Proteins

Autophagy is an evolutionarily conserved cellular catabolic pathway in response to metabolic stresses. Autophagy is activated with the formation of double membrane structures named autophagosome, which can ferry cytoplasmic impaired organelles and proteins to the lysosome for degradation. Autophagy is regarded as a quality control mechanism that contributes to the maintainance of cell homeostasis. By far, the core proteins involved in the classical autophagy pathway have been identified. The activity and function of these proteins in autophagy flux following stress signal inputs is being investigated. We reviewed recent studies about the regulation of autophagy related proteins with posttranslational modifications under conditions of metabolic stresses, in order to help the further understanding of autophagy.