Mediation of serotonin-induced hyperventilation via 5-HT3-receptor in European eel Anguilla anguilla |
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Authors: | J -J Janvier M Peyraud-Waïtzenegger P Soulier |
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Institution: | (1) Laboratoire de Physiologie Animale, Faculté des Sciences et Techniques, 6 Avenue Victor Le Gorgeu, F-29287 Brest, France |
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Abstract: | The effects of serotonin (5-hydroxytryptamine) on ventilation were investigated by continuous measurements of intrabuccal pressure in unrestrained eel. Intravenous administration of 5-hydroxytryptamine (30 g·kg-1) caused a large increase in ventilatory frequency (+100%) and amplitude (+140%). The 5-hydroxytryptamine-induced hyperventilation was blocked by the 5-HT3-receptor antagonists metoclopramide (1.0 mg·kg-1) or MDL72222 (1.0 mg·kg-1), and was insensitive to the 5-HT1/2-receptor antagonist methysergide (3.0 mg·kg-1) and to the 5-HT4-receptor antagonist DAU 6285 CL (3.0 mg·kg-1). The hyperventilatory response to 5-hydroxytryptamine could be mimicked by the 5-HT3 receptor agonist 1-phenylbiguanide (300 g·kg-1). These results strongly implicate the 5-HT3-receptor as the mediator of the 5-hydroxytryptamine-induced hyperventilation in eel.Abbreviations
a.u.
arbitrary units
- 5-HT
5-hydroxytryptamine
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SEM
standard error of mean
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VA
ventilatory amplitude
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VF
ventilatory frequency
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RBI
1-phenylbiguanide |
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Keywords: | Fish Serotonin Ventilation Serotonergic receptors Eel Anguilla anguilla |
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