Piperazine: An excellent catalyst for the synthesis of 2-amino-3-cyano-4H-pyrans derivatives in aqueous medium |
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| Institution: | 1. Department of Chemistry, College of Science, University of Guilan, Rasht, 41335-19141, Iran;2. Department of Chemistry, College of Science, University of Guilan, University Campus 2, Rasht, Iran;1. National Engineering Research Center of Pesticide (Tianjin), State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, People''s Republic of China;2. Key Laboratory for Water Environment and Resources, Tianjin Normal University, Tianjin, 300387, People''s Republic of China;1. BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Pusan 609-735, Republic of Korea;2. College of Pharmacy, Pusan National University, Pusan 609-735, Republic of Korea;3. Department of Food & Drug, Chosun University, Gwangju 501-759, Republic of Korea |
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| Abstract: | An improved, forthright, and highly efficient one-pot synthesis of a wide range of pharmaceutically exciting diverse kind of functionalized 2-amino-3-cyano-4H-pyrans and especially bis-pyrans compounds is developed using piperazine as a low-cost and environmentally benign commercially available basic catalyst in aqueous media. The attractive features of this process are simple procedure, short reaction times, high yields, no column chromatographic separation and commercial availability and recyclability of the catalyst. Also, piperazine can catalyze the synthesis of the target compounds on a larger scale. Furthermore, rational mechanism was suggested via GC-Mass analysis of the trapped intermediates. |
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| Keywords: | Basic catalyst Piperizine Green reaction Aqueos medium condition |
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