Cytotoxic ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata |
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| Institution: | 1. Department of Pharmaceutical Sciences, State University of Ponta Grossa, Carlos Cavalcanti Avenue, 4748, Uvaranas, Ponta Grossa, Paraná 84030-900, Brazil;2. Department of Medical Pathology, Federal University of Parana, General Carneiro Street, 460, Downtown, Curitiba, Paraná 80060-900, Brazil;3. Department of Structural and Molecular Biology and Genetics, State University of Ponta Grossa, Carlos Cavalcanti Avenue, 4748, Uvaranas, Ponta Grossa, Paraná 84030-900, Brazil;4. National Center for Natural Products Research, University of Mississippi, MS 38677, USA;5. Department of Dendistry, State University of Ponta Grossa, Carlos Cavalcanti Avenue, 4748, Uvaranas, Ponta Grossa, Paraná 84030-900, Brazil |
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| Abstract: | Euphoroids A–C (1–3), three new ent-abietane-type diterpenoids, together with ten known analogues (4–13) were obtained from the roots of Euphorbia ebracteolata. The structures of these compounds were determined by extensive spectroscopic data analysis, including UV, HRESIMS, 1D-, and 2D-NMR data. The inhibitory effects of compounds 1–13 on human cancer cells were determined using the MTT assay. The results revealed that new compounds 2 and 3 showed moderate cytotoxic activities against human cancer cell lines. Especially, compound 3 displayed selective cytotoxic effect agains cancer cell lines. |
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| Keywords: | Diterpenoids Abietane Cytotoxic activities |
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