Potential antioxidant activity of Morita-Baylis-Hillman adducts |
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| Institution: | 1. Laboratoire de Chimie Organique Structurale LR99ES14, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, 2092 Tunis, Tunisia;2. Laboratoire de Biotechnologie Moléculaire des Eucaryotes, Centre de Biotechnologie de Sfax, Université de Sfax, Tunisia;3. Laboratoire de Chimie des Substances Naturelles UR11-ES74, Faculté des Sciences de Sfax, BP 1171, 3000 Sfax, Tunisia;1. Department of Plant Protection, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran;2. Department of Plant Protection, Faulty of Agriculture, University of Zanjan, Zanjan, Iran;3. School of Environmental and Rural Sciences, University of New England, Armidale, Australia;1. Chemistry Department, Federal University of Juiz de Fora, Cidade Universitária, São Pedro, Juiz de Fora, MG, 36036-900, Brazil;2. Laboratory of Synthesis of Natural Products and Drugs, Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, 13083-970, Campinas, SP, Brazil;1. Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, Vilnius, LT-03225, Lithuania;2. Department of Molecular Cell Biology, Institute of Biochemistry, Vilnius University, Mokslinink? 12, Vilnius, LT-08662, Lithuania;3. Department of Bioinformatics, Institute of Biotechnology, Vilnius University, V. Grai?iūno 8, Vilnius, LT-02241, Lithuania;4. Department of Applied Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, Vilnius, LT-03225, Lithuania |
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| Abstract: | The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity.As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates. The obtained results showed that the strongest DPPH radical scavenging activity was observed in the case of hydrazonophosphonates in comparison to the other MBH derivatives. |
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| Keywords: | DPPH Phosphonates Hydrazones Morita-Baylis-Hillman adducts |
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