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Lnc’ing Ca2+, SERCA and cardiac disease |
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| Institution: | 1. Department of physiology and pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi''an, China;2. Department of dermatology, Chinese PLA General Hospital, Beijing, China;3. Department of pathology, Xijing Hospital, Fourth Military Medical University, Xi''an, China |
| Abstract: | Loss of SERCA function contributes to reduced contractility, Ca2+ overload and arrhythmias in the diseased heart. A long non-coding RNA (ZFAS1) upregulated in cardiac disease is reported to directly inhibit SERCA function. The implications for cardiac disease and the wider roles of SERCA are discussed. |
| Keywords: | SERCA Excitation contraction coupling/ECC Long non coding RNA/lncRNA Calcium/Ca2 Cardiac myocytes |
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