Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents |
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| Institution: | 1. Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia;2. Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt;3. Department of Pharmaceutical Chemistry, Pharmacy College, Taif University, Taif 888, Saudi Arabia;4. Department of Epidemic Disease Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia;5. Department of Health Informatics, College of Public Health and Health Informatics, Qassim University, Al Bukayriyah, Saudi Arabia;6. Department of Basic Science (Chemistry), College of Science and Humanities, Shaqra University, Afif, Saudi Arabia;7. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia;8. Departmentof Pharmacology and Toxicology, National Center for Research, Medicinal and Aromatic Plants Research Institute, Khartoum 2404, Sudan;9. Department of Chemistry, Jamoum University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia;10. Research Laboratories Unit, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia |
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| Abstract: | Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates. |
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| Keywords: | Amino acids Peptides Conjugation Heterocycles Biological activities SAR |
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