Toxic levels of selenium in enzymes and selenium uptake in tissues of a marine fish |
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| Authors: | Laura Tallandini Rodolfo Cecchi Silvia De Boni Silvio Galassini Grazia Ghermandi Giancarlo Gialanella Nianqing Liu Renata Moro Margherita Turchetto Yuanxung Zhang |
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| Institution: | (1) Dipartimento di Biologia, Universitá di Padova, Padova, Italy;(2) Dipartimento di Scienza dell’Ingegneria, Universitá di Modena, Modena, Italy;(3) Istituto di Chimica Biologica, Universitá di Verona, Verona, Italy;(4) Osservatorio Geofisico, Universitá di Modena, Modena, Italy;(5) Dipartimento di Scienze Fisiche, Universitá di Napoli “Federico II”, Napoli, Italy;(6) Laboratori Nazionali dell’INFN, Legnaro (Padova), Italy;(7) Institute of High Energy Physics, Academia Sinica, Beijing, China;(8) Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Italy;(9) Shangai Institute of Nuclear Research, Shangai, China |
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| Abstract: | Acute toxicity of selenium as selenite inZosterisessor ophiocephalus by ip injection was studied. The 50% lethal dose and 50% lethal time were measured to be 0.29 ppm and 96 h, respectively.
Se concentrations in liver, gill, skin and muscle, and Cyt. P450 level, Se-GPx, and Total GPx enzyme activities in liver were
also assessed at different doses and times after injection. Starting at 0.3 ppm injected dose, enzyme activities and Se concentration
in tissues but not in muscle, showed significant differences from the control group. A threshold behavior was inferred. Normal
conditions of enzyme activities and Se concentration in tissues were restored about 1 wk after injection. Biological elimination
half-lives were about 2 d for liver and gill, and 5 d for skin. |
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| Keywords: | Selenium toxicity fish 50% lethal time and lethal dose effect on Cyt P450 Se GPx and total GPx enzymes Se tissue contents |
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