|
|||||
|
|
Acid stress damage of DNA is prevented by Dps binding in <Emphasis Type="Italic">Escherichia coli</Emphasis>O157:H7 |
|
| Authors: | Kwang Cheol Jeong Kai Foong Hung David J Baumler Jeffrey J Byrd Charles W Kaspar |
| Institution: | (1) Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA;(2) Cellular and Molecular Biology Program, University of Wisconsin, Madison, WI 53706, USA;(3) Department of Biology, St. Mary's College of Maryland, St. Mary's City, MD 20686, USA;(4) Department of Molecular Microbiology, Washington University, St. Louis, MO 63130, USA;(5) Genome Center of Wisconsin, University of Wisconsin, Madison, WI 53706, USA |
| Abstract: | BackgroundAcid tolerance in Escherichia coli O157:H7 contributes to persistence in its bovine host and is thought to promote passage through the gastric barrier of humans. Dps (DNA-binding protein in starved cells) mutants of E. coli have reduced acid tolerance when compared to the parent strain although the role of Dps in acid tolerance is unclear. This study investigated the mechanism by which Dps contributes to acid tolerance in E. coli O157:H7. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |