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A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng
Authors:Deepak Poudyal  Xiangli Cui  Phuong Mai Le  Anne B. Hofseth  Anthony Windust  Mitzi Nagarkatti  Prakash S. Nagarkatti  Aaron J. Schetter  Curtis C. Harris  Lorne J. Hofseth
Abstract:Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anti-cancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expression profiling, we observed increased miR-29b in colon cancer cells following exposure to HAG. Since miR-29b plays a role in regulating the migration of cancer cells, we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 (MMP-2) thereby suppressing the migration of colon cancer cells. Results are consistent with this hypothesis. Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells.
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