Effect of an acute zinc depletion on rat lipoprotein distribution and peroxidation |
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Authors: | P Faure A M Roussel M J Richard T Foulon P Groslambert A Hadjian A Favier |
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Institution: | 1. Laboratoire de Biochimie C., H?pital A. MICHALLON, BP 217X, 38043, Grenoble Cédex, France 2. Laboratoire de Biochimie, U.F.R. de pharmacie, 38700, La Tronche, France 3. Laboratoire de Biochimie A, Centre Hospitalier Régional, 38043, Grenoble Cédex, France
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Abstract: | The aim of this study was to determine the extent to which zinc depletion leads to lipoprotein modifications by measuring
both lipoprotein-fraction distribution and peroxidation in zinc-depleted rats.
The animals were divided into three groups and fed for 8 wk a zinc-adequate diet (100 ppm) ad libitum (AL), a zinc-deficient
diet (0.2 ppm) ad libitum (ZD), or a zinc-adequate diet according to the pair feeding method (PF).
Trace-element status, tissular lipids, and lipoprotein-fraction study were performed. The MDA production by the lipoprotein
fraction was measured before and after induced peroxidation.
Cholesterol and phospholipids were increased in ZD rats. An important increase of VLDL and IDL was observed and a significant
enhanced production of MDA by the LDL was related to zinc deficiency. From this observation, we may conclude that LDL fractions
of ZD rats are more susceptible to induced oxidative damage.
These results suggest that in zinc deficiency, the lipoprotein fragility is an aggravating factor of peroxidation and the
dyslipoproteinemia may lead to an atherogenic risk. |
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Keywords: | Zinc-deficient rats lipoprotein fractions lipid peroxidation |
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