A new lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models |
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| Authors: | Peroni Elisa Caminati Gabriella Baglioni Piero Nuti Francesca Chelli Mario Papini Anna M |
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| Affiliation: | Dipartimento di Chimica Organica Ugo Schiff, Università degli Studi di Firenze, Polo Scientifico, I-50019 Sesto Fiorentino (FI), Italy. |
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| Abstract: | The new fluorescent lipophilic moiety 11-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-acetyl)amino]undecanoic acid (AMCA-omegaAud-OH) was introduced by SPPS at the N-terminus of the immunodominant epitope GpMBP(74-85). FRET experiments using the new fluorescent lipopeptide demonstrate that the peptide interacts with much more affinity with the membrane compared to the lipid free analogue. |
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