Ribosome and the Secret of Longevity (A Hypothesis) |
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| Authors: | Ryazanov A. G. |
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| Affiliation: | (1) Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, 08854, NJ, USA |
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| Abstract: | Proteins in cells are constantly undergoing damage. Nevertheless, the concentration of damaged proteins in young organisms is maintained at a low level owing to the continual protein turnover: breakdown of damaged proteins and synthesis of new ones. During aging, the concentration of damaged proteins increases because of decelerating protein turnover, the cause of which is unknown; however, it may be related to the decrease in ribosome concentration. |
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