| 红藻凝集素G研究进展 |
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| 引用本文： | 李兰,郑其升,侯继波. 红藻凝集素G研究进展[J]. 微生物学报, 2019, 59(10): 1872-1879 |
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| 作者姓名： | 李兰 郑其升 侯继波 |
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| 作者单位： | 江苏省农业科学院国家兽用生物制品工程技术研究中心, 江苏 南京 210014,江苏省农业科学院国家兽用生物制品工程技术研究中心, 江苏 南京 210014,江苏省农业科学院国家兽用生物制品工程技术研究中心, 江苏 南京 210014;江苏省动物重要疫病与人兽共患病防控协同创新中心, 江苏 扬州 225009 |
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| 基金项目： | 国家自然科学基金（31772701）；江苏省农业科技自主创新资金[CX（18）3011] |
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| 摘 要： | 来源于海洋红藻的凝集素G已被证实对多种囊膜病毒都有抗病毒活性,可与囊膜病毒表面糖基结合而阻断病毒的入侵。以病毒入侵为作用靶点的抗病毒药物,不仅可以阻断病毒的自由传播途径,还可以阻断细胞间传播途径,红藻凝集素G还具有可溶性好、易表达、稳定性强、免疫原性低、安全性好等优点,所以红藻凝集素G作为一类新型抗病毒药物越来越受到科学家的青睐。
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| 关 键 词： | 凝集素 囊膜病毒糖蛋白 抗病毒 安全性 |
| 收稿时间： | 2018-10-30 |
| 修稿时间： | 2019-01-17 |
Research progress of griffithsin |
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| Lan Li,Qisheng Zheng and Jibo Hou. Research progress of griffithsin[J]. Acta microbiologica Sinica, 2019, 59(10): 1872-1879 |
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| Authors: | Lan Li Qisheng Zheng Jibo Hou |
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| Affiliation: | National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu Province, China,National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu Province, China and National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu Province, China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu Province, China |
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| Abstract: | Griffithsin, originally isolated from Griffithsia spp. marine red algae., is a broad-spectrum antiviral lectin that inhibits viral entry through binding to viral glycoproteins. Drugs that inhibit virus''s entry prevent infection of cells by cell-free virus particles and also prevent virus transmission between virus-infected and uninfected cells. Besides, griffithsin also has the advantages of good solubility, easy expression, strong stability, low immunogenicity and good safety. Thus, griffithsin, as a new potential class of antiviral drugs, has got the favor of scientists. |
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| Keywords: | lectin viral envelope glycoproteins antiviral safety |
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