| 脑脊液蛋白质组技术及临床应用研究进展 |
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| 引用本文： | 杨林鹏,樊鹏程,靳婉君,马慧萍,景临林,贾正平.脑脊液蛋白质组技术及临床应用研究进展[J].生物工程学报,2019,35(9):1643-1649. |
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| 作者姓名： | 杨林鹏 樊鹏程 靳婉君 马慧萍 景临林 贾正平 |
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| 作者单位： | 1 中国人民解放军联勤保障部队第九四〇医院 全军高原环境损伤防治重点实验室，甘肃 兰州 730050;3 兰州大学 药学院，甘肃 兰州 730000,2 北京生命组学研究所 国家蛋白质科学中心(北京) 北京蛋白质组学研究中心 蛋白质组学国家重点实验室，北京 102206,1 中国人民解放军联勤保障部队第九四〇医院 全军高原环境损伤防治重点实验室，甘肃 兰州 730050;4 甘肃省中医药大学 药学院，甘肃 兰州 730000,1 中国人民解放军联勤保障部队第九四〇医院 全军高原环境损伤防治重点实验室，甘肃 兰州 730050;4 甘肃省中医药大学 药学院，甘肃 兰州 730000,1 中国人民解放军联勤保障部队第九四〇医院 全军高原环境损伤防治重点实验室，甘肃 兰州 730050,1 中国人民解放军联勤保障部队第九四〇医院 全军高原环境损伤防治重点实验室，甘肃 兰州 730050;3 兰州大学 药学院，甘肃 兰州 730000 |
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| 基金项目： | 国家自然科学基金 (Nos. 81402848, 81571847)，中国博士后科学基金 (Nos. 2016T91005, 2015M582804)，甘肃省自然科学杰出青年基金项目 (No. 145RJDA331) 资助。 |
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| 摘 要： | 脑脊液(CSF)围绕并支持中枢神经系统(CNS),包括脑室和蛛网膜下腔,由于脑脊液与中枢神经系统直接接触,所以其是寻找中枢神经系统疾病生物标记物的重要来源。国内外学者开展了大量CSF蛋白质组学的研究工作,并取得了较大进展。文中综述了近年来CSF蛋白质组学技术及临床应用研究进展。
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| 关 键 词： | 脑脊液，蛋白质组学，临床应用，质谱，诊断标志物 |
| 收稿时间： | 2019/4/6 0:00:00 |
Progress in cerebrospinal fluid proteome technology and its clinical application |
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| Linpeng Yang,Pengcheng Fan,Wanjun Jin,Huiping M,Linlin Jing and Zhengping Jia.Progress in cerebrospinal fluid proteome technology and its clinical application[J].Chinese Journal of Biotechnology,2019,35(9):1643-1649. |
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| Authors: | Linpeng Yang Pengcheng Fan Wanjun Jin Huiping M Linlin Jing and Zhengping Jia |
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| Institution: | 1 Key Laboratory of Prevention and Cure for the Plateau Environmental Damage of PLA, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, Gansu, China;3 School of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China,2 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China,1 Key Laboratory of Prevention and Cure for the Plateau Environmental Damage of PLA, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, Gansu, China;4 College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China,1 Key Laboratory of Prevention and Cure for the Plateau Environmental Damage of PLA, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, Gansu, China;4 College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China,1 Key Laboratory of Prevention and Cure for the Plateau Environmental Damage of PLA, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, Gansu, China and 1 Key Laboratory of Prevention and Cure for the Plateau Environmental Damage of PLA, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, Gansu, China;3 School of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China |
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| Abstract: | Cerebrospinal fluid surrounds and supports the central nervous system, including the ventricles and subarachnoid spaces. Cerebrospinal fluid should be an important source of biomarkers for central nervous system diseases because it is in direct contact with the central nervous system. Many studies are reported on cerebrospinal fluid proteomics, highlighting many recent progresses. Here, we review recent advances in proteomics technology and clinical application of cerebrospinal fluid. |
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| Keywords: | cerebrospinal fluid proteomics clinical application mass spectrometry diagnostic markers |
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