| 微生物-肠-脑轴的研究进展 |
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| 引用本文： | 高侃,慕春龙,朱伟云.微生物-肠-脑轴的研究进展[J].微生物学报,2019,59(9):1737-1746. |
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| 作者姓名： | 高侃 慕春龙 朱伟云 |
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| 作者单位： | 动物消化道营养国家级国际联合研究中心, 江苏省消化道营养与动物健康重点实验室, 南京农业大学消化道微生物研究室, 江苏 南京 210095,动物消化道营养国家级国际联合研究中心, 江苏省消化道营养与动物健康重点实验室, 南京农业大学消化道微生物研究室, 江苏 南京 210095,动物消化道营养国家级国际联合研究中心, 江苏省消化道营养与动物健康重点实验室, 南京农业大学消化道微生物研究室, 江苏 南京 210095 |
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| 基金项目： | 国家自然科学基金（31430082）；国家重点基础研究发展计划（973项目）（2013CB127300） |
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| 摘 要： | 肠道微生物群能够调节宿主肠道稳态,同时参与调节宿主神经系统功能和行为。肠道菌群失调可能导致宿主神经系统功能障碍,从而引发神经退行性疾病。因此,研究微生物在肠?脑轴中发挥的作用及其机制,靶向调控肠道微生物菌群结构和功能,将为神经系统疾病的诊断与治疗提供新的手段。近年来,有关肠道微生物与机体神经系统间的互作研究受到了广泛关注,然而其具体的调控机制还未明晰。因此,本文综述了肠道微生物对宿主神经健康的调节作用,以及肠道微生物与宿主间的互作在调节神经功能、行为的潜力等研究进展,为更好地了解肠道微生物在调控宿主神经系统功能和行为的作用机制提供参考。
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| 关 键 词： | 肠道微生物 代谢产物 肠-脑轴 神经系统 |
| 收稿时间： | 2018/8/17 0:00:00 |
| 修稿时间： | 2018/12/3 0:00:00 |
Advances in microbiota-gut-brain axis |
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| Kan Gao,Chunlong Mu and Weiyun Zhu.Advances in microbiota-gut-brain axis[J].Acta Microbiologica Sinica,2019,59(9):1737-1746. |
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| Authors: | Kan Gao Chunlong Mu and Weiyun Zhu |
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| Institution: | Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China,Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China and Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China |
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| Abstract: | The gut microbiota regulates intestinal homeostasis, and also participates in the modulation of brain function and behaviors of hosts. Disorders of gut microbiota are associated with the dysfunction of host nervous system, causing the development of neurodegenerative diseases. Thus, better understanding the role of gut microbiota in the gut-brain axis can provide new strategies for the diagnosis and treatment of nervous system diseases by the targeted modulation of gut microbiota composition and function. In recent years, studies on the interaction between gut microbiota and brain function have been reported, but the underlying mechanisms are still not fully understood. Therefore, combining with the latest research findings from our laboratory, we review here the modulatory effects of gut microbiota on nervous system and the potential role of interaction between gut microbiota and host in the modulation of brain function and behaviors of hosts, aiming to deepen our understanding about the role of gut microbiota in the modulation of brain function and behaviors in hosts. |
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| Keywords: | intestinal microbiota microbial metabolites gut-brain axis nervous system |
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