Synthesis of dissimilatory enzymes of serine type methylotrophs under different growth conditions

The synthesis of methanol dehydrogenase, formaldehyde dehydrogenase, and formate dehydrogenase by pink pigmented facultative methylotrophs (PPFM) has been studied during growth on C₁ and multicarbon substrates. In batch cultures, the methanol dehydrogenase activities were higher during slow growth on non-C₁-compounds than during fast growth on methanol. Derepression of this enzyme also occurred at slow growth in methanol-limited chemostat culture. Formaldehyde dehydrogenase and formate dehydrogenase remained largely repressed during growth on multicarbon substrates.