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Acute administration of levetiracetam in tonic pain model modulates gene expression of 5HT1A and 5HT7 receptors in the thalamus of rats (Rattus norvergicus) |
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| Authors: | Cortes-Altamirano José Luis Reyes-Long Samuel Bonilla-Jaime Herlinda Clavijo-Cornejo Denise Vargas Javier Bandala Cindy Alfaro-Rodriguez Alfonso |
| Affiliation: | 1.División de Neurociencias, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra” (INR) Secretaría de Salud (SSA), Mexico City, México ;2.Departamento de Quiropráctica, Universidad Estatal del Valle de Ecatepec (UNEVE), Estado de México, Mexico City, México ;3.Escuela Superior de Medicina, Instituto Politécnico Nacional (IPN), Mexico City, México ;4.Departamento de Biología de La Reproducción, Universidad Autónoma Metropolitana (UAM) Campus Iztapalapa, Mexico City, México ;5.División de Enfermedades Musculoesqueléticas Y Reumáticas, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra” (INR) Secretaría de Salud (SSA), Mexico City, México ;6.Neuropharmacology, Departament of Neurosciences, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México-Xochimilco 289, Col. Arenal de Guadalupe, Del. Tlalpan, 14389, Mexico City, México ; |
| Abstract: | The nociceptive effect of Levetiracetam (LEV) on the expression of 5-HT1A and 5-HT7 receptors found in the thalamus was evaluated. Thirty-six male rats (Wistar) were randomized into six groups: in the Control group without treatment; LEV50 group LEV was administered in a single dose of 50 mg/kg i.g.; in the LEV300 group LEV dose of 300 mg/kg i.g.; in the FORMALIN group the formalin test was performed; in the LEV50/FORMALIN group LEV dose of 50 mg/kg i.g and the formalin test was performed; in the LEV300/FORMALIN group LEV dose of 300 mg/kg i.g and the formalin test was performed, subsequently the thalamus was dissected in all groups. In the formalin tests LEV exhibited an antinociceptive effect in the LEV300/FORMALIN group (p?1A and 5-HT7 receptors in the thalamus, 5-HT1A receptors increased significantly in the FORMALIN group and the LEV300/FORMALIN group (p?1A and 5-HT7 in a tonic pain model, and that changes in the expression of 5-HT1A and 5-HT7 receptors are associated with the sensation of pain, furthermore its possibility to be used in clinical treatments for pain. |
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