基于微流控芯片的秀丽隐杆线虫的研究进展

微流控芯片技术作为近年来最前沿的分析技术之一,已经在化学、生物学、医药学等研究领域取得了突破性的进展.微流控芯片具有高通量、微型化和多功能集成化等独特优势,已经成为生物医学研究的新平台之一,被越来越多地应用于秀丽隐杆线虫的研究.综述了基于微流控芯片上的秀丽隐杆线虫在生物医学领域中的研究进展,侧重介绍了微流控芯片在线虫的自动化固定、行为学、衰老与发育学、神经学、药物筛选及基因筛选等六大方面所取得的最新进展,并展望了微流控芯片的应用前景.

Advances on biomedical research in Caenorhabditis elegans based on microfluidic device

Microfluidic chip, which is one of the most fascinating analytical technologies in recent years, has made striking progress in chemistry, biology, medicine and other research fields. Several unique properties of microfluidics, such as high-throughput, miniaturization and multifunctional integration, make them ideal for their applications in biomedical research. More and more efforts have been dedicated to the research of Caenorhabditis elegans on a microfluidic platform for the past ten years. The related progress for biomedical purpose of Caenorhabditis elegans was reviewed. In particular, advances on microfluidic-based researches have been focused. The automated immobilization, behaviors, development, neurology, drug screening and gene screening of Caenorhabditis elegans were summarized. The prospects for the applications of microfluidic device are also discussed.