Cyclazocine revisited |
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Authors: | Sydney Archer Stanley D Glick Jean M Bidlack |
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Institution: | (1) Department of Chemistry, Rensselaer Polytechnic Institute, 2180-3590 Troy, NY;(2) Department of Pharmacology and Neuroscience, Albany Medical College, 12208-3479 Albany, NY;(3) Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, 14642-8711 Rochester, NY |
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Abstract: | Recently synthesized compounds which have long-term mu antagonist activity and short-term kappa agonist effects prevent self-administration
of cocaine and morphine in rats. Cyclazocine, a compound synthesized in 1962 and studied in animals and man in the 1960's
and in the early 1970's is a mu antagonist in rats and man and is a potent kappa agonist in both species. It also prevents
self-administration of cocaine and morphine in rats. Although it produces unpleasant side effects in man, subjects become
tolerant to these side effects but not to the antagonistic actions of the drug after prolonged administration.
Deceased
Special issue dedicated to Dr. Eric J. Simon. |
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Keywords: | Cyclazocine mu antagonist kappa agonist |
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