| S／D法处理凝血因子浓缩物类制品的病毒灭活验证 |
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| 引用本文： | 邱平,周铁群,王剑锋,李长贵,汪兴太.S／D法处理凝血因子浓缩物类制品的病毒灭活验证[J].微生物学免疫学进展,2000,28(1):44-46. |
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| 作者姓名： | 邱平 周铁群 王剑锋 李长贵 汪兴太 |
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| 作者单位： | 中国药品生物制品检定所!北京100050 |
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| 摘 要： | 以水泡性口炎病毒 (VSV)为指示病毒 ,验证应用有机溶剂 /去污剂 (简称S/D)法灭活血液制品中病毒的生产工艺 ,并对不同厂家不同批号的四种凝血因子浓缩物类制品 (中间品 )的病毒灭活效果进行了分析总结。结果表明当制品中TNBP和Tween80终浓度为 0 3%和 1 0 % ,在 2 5± 1℃处理 6小时后对于包膜病毒确有显著的灭活效果。
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| 关 键 词： | 凝血因子浓缩物 S／D处理 病毒灭活验证 |
Validation of virus inactivation in coagulation factors with S/D treatment |
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| QIU Ping,ZHOU Tiequn,WANG Jianfeng,et al.Validation of virus inactivation in coagulation factors with S/D treatment[J].Progress In Microbiology and Immunology,2000,28(1):44-46. |
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| Authors: | QIU Ping ZHOU Tiequn WANG Jianfeng |
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| Abstract: | Effects of S/D treatment on inactivation of lipidenvelope marker virus,vesicular stomatitis virus(VSV)in the production process of blood products were investigated on a laboratory scale.The results showed that VSV can be significantly inactivated by S/D treatment. |
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| Keywords: | Coagulation Factors S/D treatment Virus inactivation |
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