Induction of hepatic microsomal gamma-glutamyltransferase activity following chronic alcohol consumption. |
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| Authors: | R Teschke A Brand G Strohmeyer |
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| Institution: | Second Department of Medicine, University of Düsseldorf, 4000 Düsseldorf, Federal Republic of Germany |
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| Abstract: | Chronic alcohol consumption for 4–5weeks results in an enhancement of serum gamma-glutamyltransferase activity in rats. Concomitantly, an increase of hepatic gamma-glutamyltransferase was observed. Upon subcellular fractionation of liver homogenates by ultracentrifugation, an induction of gamma-glutamyltransferase activity could be demonstrated in the microsomal fraction of the hepatocyte. These findings suggest that increased serum gamma-glutamyltransferase activities commonly observed in alcoholism can be ascribed at least in part to an induction of microsomal gamma-glutamyltransferase activity. |
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