Diaryloxy methano phenanthrenes: a new class of antituberculosis agents |
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Authors: | Panda Gautam Shagufta Mishra Jitendra Kumar Chaturvedi Vinita Srivastava Anil K Srivastava Ranjana Srivastava Brahm S |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India. gautam_panda@lycos.com |
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Abstract: | A new series of diaryloxy methano phenanthrenes were prepared through tertiary-aminoalkylations of (methoxy-phenyl)-phenanthren-9-yl-methyl]-phenols obtained from Friedel-Crafts alkylations on (methoxy-phenyl)-phenanthren-9-yl-methanols. These series of compounds were evaluated against Mycobacterium tuberculosis H37Rv and showed the desired activity in the range of 6.25 microg/mL in vitro. One of the compound 12j protects the mice from the challenge of M. tuberculosis in vivo, as 30% of the mice were survived at treatment of 50 mg/kg body weight. |
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