Meiotic chromosome distribution in Drosophila oocytes: Roles of two kinesin-related proteins |
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Authors: | Sharyn A Endow |
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Institution: | (1) Department of Microbiology, Duke University Medical Center, 27710 Durham, NC, USA |
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Abstract: | Summary The recent finding that two proteins required for proper chromosome distribution in Drosophila oocytes are related to the microtubule motor protein, kinesin, provides new insights into the forces involved in meiotic chromosome movement. ncd is a spindle motor in meiosis but may perform a different role in the early mitotic divisions of the embryo. nod, until recently, has been thought to be a component of the distributive process of chromosome segregation. The finding that nod is a kinesin protein provides an alternative explanation of the effect of mutants on nonexchange chromosomes and suggests that nonexchange chromosomes segregate with exchange chromosomes in a single process, rather than via a two-step distributive system. |
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