Increased erythromycin production by alginate as a medium ingredient
or immobilization support in cultures of <Emphasis Type="BoldItalic">Saccharopolyspora erythraea</Emphasis> |
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Authors: | Email author" target="_blank">J?HamediEmail author F?Khodagholi A?Hassani-Nasab |
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Institution: | (1) Microbial Biotechnology Laboratory, Department of Biology, Faculty of Science, University of Tehran, Tehran, Iran |
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Abstract: | Erythromycin production by Saccharopolyspora erythraea immobilized in 2% (w/v) calcium alginate or grown in medium containing 20 g sodium alginate/l inoculated with free cells was almost twice more than that of the control. S. erythraea did not consume alginate, agar, dextran, silicon antifoaming agent or cyclodextrin as a carbon source, although, all of these increased the production of erythromycin. Highest titer of erythromycin (2.3 times more than that of the control) was achieved in medium containing 1 g agar/l. |
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Keywords: | alginate erythromycin immobilization Saccharopolyspora erythraea shear |
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