Enhancement of producing catharanthine by suspension growth ofCatharanthus roseus |
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| Authors: | Hyung H. Park Suk K. Choi Jae K. Kang Hyeon Y. Lee |
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| Affiliation: | (1) Department of Food Engineering, Kangweon National University, 200-701 Chuncheon, Korea |
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| Abstract: | Summary Increased production of catharanthine (about 200  g/mL) was obtained at low light intensity under chemostat cultivation as compared with batch and fed-batch processes. Photo-inhibition was observed at high light intensity. Cells after being frozen with 5% DMSO produced more catharanthine (up to 350 g/L) in batch culture than those from conventional culture techniques. |
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