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Lipoprotein uptake by vascular smooth muscle cells of the rat cultured in 5% or 20% oxygen
Authors:Dr Karen S Kuehl  Peter W Holloway
Institution:1. Department of Pediatrics and Physiology, University of Virginia School of Medicine, Charlottesville, Va., USA
3. Department of Biochemistry, University of Virginia School of Medicine, Charlottesville, Va., USA
Abstract:Freshly dispersed aortic smooth muscle cells of the rat were grown in either 5% or 20% oxygen. Cells proliferated more rapidly in 5% than in 20% oxygen although at confluency the protein content per cell was 20% less in the 5% than in the 20% oxygen environment. By electron microscopy, cell morphology was the same in both environments. Uptake of low-density and high-density homologous lipoprotein was unaffected by oxygen tension. Other studies, however, showed that induction of receptors for lipoprotein binding behaved variably in the low compared to the high oxygen condition. These differences were not associated with differences in lipid synthesis in the two conditions.
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