Polyisoprenyl phosphate specificity of UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli |
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Authors: | Rush, Jeffrey S. Rick, Paul D. Waechter, Charles J. |
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Affiliation: | Department of Biochemistry, University of Kentucky College of Medicine Lexington, KY 40536, USA 1Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences Bethesda, MD 20814, USA |
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Abstract: | N-Acetyl-D-glucosaminylpyrophosphorylundecaprenol (GlcNAc-P-P-Und),an intermediate in the biosynthesis of the enterobacterial commonantigen in E.coli and some O-antigen chains in gram-negativebacteria, is formed by the transfer of GlcNAc 1-P from UDP-GlcNActo Und-P, analogous to the reaction forming GlcNAc-P-P-dolichol(GlcNAc-P-P-Dol) in mammalian cells. Since the micro-somal enzymefrom animal cells exhibits a strong preference for Dol-P, whichcontains a saturated |
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