Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen |
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| Authors: | Annunziata Rita Benaglia Maurizio Cinquini Mauro Cozzi Franco Puglisi Alessandra |
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| Affiliation: | Centro CNR and Dipartimento di Chimica Organica e Industriale, Universita' degli Studi di Milano, Via Golgi 19, I-20133, Milan, Italy. |
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| Abstract: | An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stereoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. |
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