Regulation of TOR by small GTPases |
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Authors: | Durán Raúl V Hall Michael N |
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Institution: | Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. |
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Abstract: | TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases. |
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Keywords: | TOR Rheb Rag RalA Rac1 Ryh1 |
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