Distribution of polymorphic gene duplication at theGpdh locus in natural populations ofDrosophila melanogaster |
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| Authors: | A. Koga H. Baba S. Kusakabe M. Hattori T. Mukai |
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| Affiliation: | (1) Department of Biology, Faculty of Science, 812 Fukuoka, Japan;(2) Research Laboratory for Genetic Information, Kyushu University, 812 Fukuoka, Japan;(3) Present address: Department of Environmental Sciences, Faculty of Integrated Arts and Sciences, Hiroshima University, 730 Hiroshima, Japan;(4) Present address: Institute of Medical Science, University of Tokyo, 108 Minato-ku, Tokyo, Japan |
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| Abstract: | Summary The glycerol-3-phosphate dehydrogenase (GPDH, E. C. 1.1.1.8) gene ofDrosophila melanogaster contains a tandem duplication of a 4.5-kb-long DNA fragment. Survey of theGpdh gene region by the Southern blot analysis revealed the following features of this gene duplication: (1) The duplication was not observed in chromosome lines that carryIn(2L)t, a cosmopolitan chromosomal inversion in this species. The duplication and the inversion are in linkage disequilibrium. (2) The duplication is polymorphic in the Japan and US natural populations examined. Its frequency is 0.26 on an average inIn(2L)t-free chromosomes. (3) Triplication is absent or has not become frequent in the populations surveyed. Possible evolutionary factors of this duplication polymorphism are discussed. |
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| Keywords: | Gene duplication Gpdh gene Polymorphism Drosophila melanogaster |
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