Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats |
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Authors: | Tanaka Mitsuru Matsui Toshiro Ushida Yusuke Matsumoto Kiyoshi |
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Institution: | Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan. |
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Abstract: | In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer. |
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