Genotoxicity of the some selective estrogen receptor modulators: a review |
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Authors: | Serkan Yilmaz ?lknur M Gönenç Ebru Yilmaz |
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Institution: | .Faculty of Health Sciences, Ankara University, Akta? Kav?a??, Alt?nda?, 06340 Ankara Turkey ;.Vocational School of Health Services, Gazi University, Gölba??, 06830 Ankara Turkey |
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Abstract: | The objective of this article is to review genotoxicological profile of the major selective estrogen receptor modulators, including clomiphene, tamoxifen, toremifene, raloxifene. These drugs have been used for infertility treatment and breast cancer prevention in high risk-women. However, some studies reported that especially tamoxifen is a genotoxic agent and is related with endometrial cancer. Our review indicate that clomiphene and tamoxifen were found as genotoxic agent in majority of the tests. However published reports showed that toremifene is a weakly genotoxic agent. The genotoxic effects of raloxifene are still poorly known. Further genotoxicity studies should be conducted especially for raloxifene. |
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Keywords: | Genotoxicity Clomiphene Tamoxifen Toremifene Raloxifene Review |
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