Gene dosage effect for glycinamide ribonucleotide synthetase in human fibroblasts trisomic for chromosome 21 |
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| Authors: | J A Bartley C J Epstein |
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| Affiliation: | 1. Department of Pediatrics University of California, San Francisco, California 94143 USA;2. Department of Biochemistry and Biophysics University of California, San Francisco, California 94143 USA |
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| Abstract: | The mean activity of glycinamide ribonucleotide synthetase of fibroblasts from fetuses with trisomy 21 is 1.64 — times that of normal cells. This gene dosage effect is confirmatory of the assignment of the gene for this enzyme to human chromosome 21. |
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