Assessment of the reproducibility of nocturnal growth hormone secretion |
| |
Authors: | J Weill M Dherbomez P Fialdes C Stuckens A Duhamel C Ponté |
| |
Institution: | Pediatric Endocrine Unit, University Hospital, Lille, France. |
| |
Abstract: | The reproducibility of measurements of nocturnal spontaneous secretion of growth hormone (GH) was assessed. The study population consisted of 15 short children with a variety of pathological conditions. Blood samples were taken every 20 min from each subject during sleep on two consecutive nights. The analysis of variance of matched series indicated a global reproducibility, but also demonstrated significant individual variabilities (with-in-subject effect) of both peak amplitude (p = 0.05) and mean concentration (p = 0.02). We did not find any link between the variation of the GH parameters and the variations of the clinical sleep score in 11 patients. |
| |
Keywords: | |
|
|