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Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity |
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| Authors: | Cho Won-Jea Min Sun Young Le Thanh Nguyen Kim Tae Sung |
| Affiliation: | College of Pharmacy, Chonnam National University, Yong-Bong dong, Buk-gu, Kwangju 500-757, South Korea |
| Abstract: | To investigate the structure–activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I–DNA complex was also performed. |
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