Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis |
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| Authors: | Sakurai Nobuko Kozuka Mutsuo Tokuda Harukuni Nobukuni Yoshitaka Takayasu Junko Nishino Hoyoku Kusano Akiko Kusano Genjiro Nagai Masahiro Sakurai Yojiro Lee Kuo Hsiung |
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| Institution: | Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA. |
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| Abstract: | Cimigenol (1) and 39 related compounds were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Structure-activity relationship analysis indicated that compound 1 showed the highest activity and also exhibited significant inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that 1 and the related compounds might be valuable anti-tumor promoters. |
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