In Vivo Immunomodulation by <Emphasis Type="Italic">Mycoplasma fermentans</Emphasis> Membrane Lipoprotein |
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Authors: | Francisco Romero Encarnación Moreno Alfonso Ruiz-Bravo María Jiménez-Valera |
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Institution: | (1) Department of Microbiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain |
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Abstract: | The immunomodulatory effects of Mycoplasma fermentans-derived membrane lipoprotein (LAMPf) in BALB/c mice were examined. When injected intraperitoneally into mice, LAMPf induced a transitory splenomegaly followed by a suppression of the spleen cell proliferation in response to concanavalin A, whereas responses to lipopolysaccharide and to LAMPf were unchanged. The intravenous injection of a large dose of LAMPf induced leukopenia and granulocyte-macrophage colony-stimulating factor (GM-CSF) activity in serum. A synthetic analogue of its N-terminal lipopeptide with ability to activate macrophages (MALP-2) was also able to induce GM-CSF in serum. Interestingly, GM-CSF induction by a low dose of MALP-2 was not associated with significant leukopenia. These data revealed that the in vitro moduline properties of mycoplasmal lipoproteins and lipopeptides correlate with interesting in vivo immunomodulatory effects. |
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