Comparative analysis of motor unit action potentials of the medial gastrocnemius muscle in cats and rats |
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| Institution: | 1. Department of Neurobiology, University School of Physical Education, Poznan, Poland;2. Department of Kinesiotherapy, University School of Physical Education, Poznan, Poland;1. Department ‘Molecules – Signals – Development,’ Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany;2. Department of Physiology, Pharmacology, and Neuroscience, City College of the City University of New York, New York, NY 10031, USA;3. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;4. Munich Cluster for Systems Neurology (Synergy), 80336 Munich, Germany;1. Institute of Psychology, Leiden University, The Netherlands;2. Leiden Institute of Brain and Cognition, Leiden University, The Netherlands;3. Department of Psychiatry, Leiden University Medical Center, The Netherlands;4. Department of Endocrinology, Leiden University Medical Center, The Netherlands;1. Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA;2. Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA;3. Computational Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA;1. Department of Molecules-Signaling-Development, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany;2. Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada;3. Integrated Program in Neuroscience, McGill University, Montréal, QC H3A 2B4, Canada;4. Division of Experimental Medicine, Department of Anatomy and Cell Biology and Department of Biology, McGill University, Montréal, QC H3A 2B2, Canada;5. Faculté de Médecine, Université de Montréal, Montréal, QC H3C 3J7, Canada;6. Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany |
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| Abstract: | Properties of motor unit action potentials (MUAPs) were compared for medial gastrocnemius (MG) motor units (MUs) in cats and rats. The experiments on functionally isolated MUs were performed under general anaesthesia, under comparable conditions (surgery, stimulating protocol and recording methods) for both species investigated. The proportions of motor units and contractile properties of the sample used in the study were consistent with previous studies performed on the MG muscle in both animal species, so comparisons of action potentials of individual types of MUs were acknowledged as fully reliable. The most prominent differences concerning MUAPs were observed in total duration and peak-to-peak times which for all MU types were about twice longer in cat MUs, in comparison to the rat MUs. The considerable disproportions were observed between the MUAP amplitudes of FF (fast fatigable), FR (fast resistant to fatigue) and S (slow) MUs in each species (the highest amplitudes were measured for FF and the lowest for S MUs), but there were no significant differences between cat and rat when respective types of MUs were compared. The shapes of MUAPs were commonly characterized by biphasic waveforms composed of two or three turns in all types of units, and no interspecies differences were revealed. Several factors influencing MUAP parameters were discussed indicating most of all importance of variable length of cat and rat muscle fibres and ambiguous influence of motor unit size, thickness of muscle fibres and their density around the recording electrode in the MG muscle of both species. |
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