Lead discovery of alpha,beta-unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression |
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| Authors: | Ni Liming Zheng X Sharon Somers Patricia K Hoong Lee K Hill Russell R Marino Elaine M Suen Ki-Ling Saxena Uday Meng Charles Q |
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| Institution: | AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, GA 30004, USA. |
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| Abstract: | alpha,beta-Unsaturated sulfones have been discovered from a combinatorial library as leads for a new series of inhibitors of inducible VCAM-1 expression. Although not essential, further conjugation of the sulfonyl group to another vinyl group or a phenyl group increases the potency dramatically. |
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